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Selank Dosage Guide: Protocols, Timing & How Much to Take (2026)

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Dosage Protocols

No FDA-approved dosing guidelines exist for Selank. The following information is derived from Russian clinical practice, published research, and community protocols:

Russian Clinical Protocol (Approved Indication):

  • 0.15% nasal spray solution (Selanc)
  • 250 to 300 mcg per administration (approximately two to three drops per nostril)
  • Three times daily
  • 14-day treatment courses
  • One-month rest period between courses

Community Intranasal Protocol:

  • Starting dose: 200 mcg intranasally, two times daily
  • Standard dose: 200 to 400 mcg intranasally, two to three times daily
  • Upper range: Up to 1,000 mcg daily (split across three or more administrations)

Subcutaneous Protocol (Less Common):

  • 200 to 500 mcg subcutaneously, once daily
  • Used when nasal spray formulation is unavailable
  • Lyophilized powder reconstituted with bacteriostatic water

Cycling Guidelines:

  • Russian clinical practice uses 14-day courses with one-month breaks
  • Community protocols often follow one month on, one month off
  • No evidence of tolerance development within 14-day courses in published data
  • Some users employ continuous low-dose protocols without cycling, though this is not supported by clinical trial data

Frequently Asked Questions

The most common intranasal protocol is 200 to 400 mcg administered two to three times daily. Russian clinical studies used 250 to 300 mcg intranasal doses in 14-day courses. Daily doses up to 1,000 mcg have been used without reported adverse effects, though doses above 300 mcg are typically split across multiple administrations.

Selank nasal spray (0.15% solution in Russia) is administered as one to two drops per nostril, two to three times daily. Each administration delivers approximately 200 to 300 mcg. The spray does not require reconstitution. Treatment courses typically last 14 days, with a one-month rest period between cycles.

This content is for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making any health-related decisions.

References

  1. Zozulya AA, Sizov SV, Syrtsev AV. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48.
  2. Kasian A, Kolomin T, Andreeva L, et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027.
  3. Zozulya AA, Kost NV, Sokolov OY, et al. A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(7):17-22.
  4. Volkova A, Shadrina M, Kolomin T, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31.
  5. Andreeva LA, Kolomin TA, Myasoedov NF. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Front Pharmacol. 2017;8:89.
  6. Kolomin T, Shadrina M, Slominsky P, et al. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul Pept. 2011;170(1-3):18-23.
  7. Kolomin T, Morozova M, Shadrina M, et al. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol Immunol. 2014;58(1):50-55.
  8. Myasoedov NF, Andreeva LA, Grigorjeva ME, et al. Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. Protein Pept Lett. 2018;25(10):914-923.
  9. World Anti-Doping Agency. The 2026 Prohibited List: International Standard.
  10. US Food and Drug Administration. Certain Bulk Drug Substances for Use in Compounding That May Present Significant Safety Risks.
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