Dosage Protocols
No FDA-approved dosing guidelines exist for Epithalon. The following information is derived from published research protocols and community reports:
Research Protocol Dosing:
- Standard protocol: 5 to 10 mg per day via subcutaneous injection for 10 to 20 consecutive days
- Cycling: Repeat once or twice per year, with 4 to 6 month intervals between cycles
- Higher doses: Some community protocols report doses above 10 mg/day, though no published data supports increased efficacy beyond the standard range
Community Dosing Protocols:
- Conservative: 5 mg subcutaneously once daily for 20 days, twice per year
- Moderate: 10 mg subcutaneously once daily for 10 days, twice per year
- Split dosing: 5 mg twice daily (morning and evening) for 10 days
Timing: Evening or bedtime administration is commonly recommended to align with natural melatonin rhythms, particularly for individuals using Epithalon with the intent of supporting circadian regulation. Epithalon is also reviewed in the [best peptides for sleep guide](/guides/best-peptides-for-sleep).
Cycling Rationale: The intermittent protocol, short treatment courses separated by months-long breaks, is based on the hypothesis that Epithalon triggers regulatory cascades that persist after the peptide itself is cleared, rather than requiring continuous receptor occupancy. This is consistent with the bioregulation framework that underpins Khavinson's research, though it has not been validated through pharmacokinetic studies in humans.