Dosage Protocols
No FDA-approved dosing guidelines exist for GHRP-2. The following protocols are derived from clinical research and practitioner experience:
- Standard range: 100 to 300 mcg per injection, administered subcutaneously one to three times daily
- Saturation dose: Approximately 1 to 2 mcg/kg body weight per injection, beyond which additional GH release plateaus
- Most common protocol: 100 to 200 mcg at bedtime, as this amplifies the natural nocturnal GH surge
Beginner Protocol
100 mcg once daily before bed, for 8 to 12 weeks. The bedtime dose is the single most important administration window because it coincides with the body's largest endogenous GH pulse.
Intermediate Protocol
150 to 200 mcg, two times daily (morning fasted and before bed), for 8 to 12 weeks. Adding a morning dose captures a second GH pulse opportunity while fasting insulin levels are low.
Advanced Protocol
200 to 300 mcg, two to three times daily, often combined with a GHRH analog such as CJC-1295 (no DAC) or Mod GRF 1-29, for 8 to 16 weeks. The synergy between GHRP-2 and a GHRH analog can amplify GH output two to three times beyond either peptide alone.
Cycling Recommendations
Cycling is recommended to maintain receptor sensitivity. A common approach is 8 to 12 weeks on followed by 4 to 8 weeks off. The peptide cycling guide covers protocols in more detail. Some practitioners use a 5-days-on, 2-days-off weekly schedule to reduce the risk of tachyphylaxis. A clinical study by Bowers et al. noted response attenuation after five consecutive days of GHRP-2 injections, reinforcing the rationale for periodic breaks.
Timing Considerations
GHRP-2 should be administered on an empty stomach, at least 30 minutes before eating or two or more hours after a meal. Elevated blood glucose and insulin significantly blunt the GH response. For the same reason, high-glycemic meals should be avoided around dosing windows.