Dosage Protocols
No FDA-approved dosing guidelines exist for ipamorelin. The following protocols are derived from clinical research and community reports:
- Standard range: 100-200 mcg per administration, with injections performed once or twice daily
- Most common protocol: 100-200 mcg administered once or twice daily, the bedtime dose is the most important, as it amplifies the natural nocturnal GH surge
Beginner Protocol
100 mcg once daily before bed, for 8-12 weeks. The bedtime dose capitalizes on the natural nocturnal GH surge and is the single most effective administration window.
Intermediate Protocol
100-200 mcg, twice daily (morning and before bed), for 8-12 weeks.
Advanced Protocol
200 mcg, two to three times daily, often combined with a GHRH analog such as CJC-1295, for 8-12 weeks.
Cycling Recommendations
Cycling is generally recommended, with 8-12 weeks on followed by 4-8 weeks off to prevent receptor desensitization and maintain pituitary sensitivity. The only published human trial used 7 days of continuous dosing; longer protocols are extrapolated from clinical rationale and community experience.
Timing Considerations
Administering ipamorelin on an empty stomach (at least 30 minutes before eating or 2 hours after) maximizes growth hormone release, as elevated blood glucose and insulin can blunt the GH response. The pre-bed dose capitalizes on the body's natural nocturnal GH surge.