Dosage Protocols
Sermorelin dosing should be individualized by a licensed healthcare provider based on the patient's age, body weight, baseline IGF-1 levels, and treatment goals. The following ranges are derived from clinical literature and prescribing conventions at compounding pharmacies:
- Standard anti-aging and wellness range: 200 to 300 mcg administered subcutaneously at bedtime, 5 to 7 nights per week
- Conservative starting dose: 100 to 200 mcg at bedtime for the first 2 to 4 weeks, titrated upward based on tolerance and clinical response
- Higher-end clinical dosing: 300 to 500 mcg at bedtime, typically reserved for patients with documented low IGF-1 levels or poor initial response
- Pediatric dosing (historical FDA-approved): 30 mcg/kg subcutaneously at bedtime, as per the original Geref labeling
Most protocols employ 5-nights-per-week dosing (weekdays on, weekends off) to balance therapeutic benefit with physiological rest periods. Some providers prescribe nightly dosing for the first 3 to 6 months before transitioning to a 5-on/2-off schedule.
Cycling is not universally required with sermorelin due to its axis-preserving mechanism, but some clinicians recommend periodic reassessment (every 3 to 6 months) with IGF-1 monitoring to adjust dosing. Unlike GH secretagogues that act on the ghrelin receptor, tolerance to sermorelin's GHRH receptor activation appears to develop slowly, if at all.