How to Use / Administration
Tesamorelin administration occurs via subcutaneous injection, typically into abdominal areas with rotating injection sites to prevent lipohypertrophy.
Preparation: Wash hands thoroughly. Allow reconstituted solution to reach room temperature if refrigerated. Inspect solution for particulates or discoloration. It should remain clear and colorless.
Injection Technique: Clean injection site with alcohol swab. Pinch skin fold and insert needle at 45-90 degree angles depending on body composition. Inject slowly and steadily, then withdraw needle and apply gentle pressure without rubbing.
Timing Optimization: Administration timing influences efficacy. Morning injection on an empty stomach (at least 2 hours after eating and 30-60 minutes before food) takes advantage of naturally lower insulin levels, as insulin can blunt GH release. Alternatively, bedtime administration aligns with natural nocturnal GH surge. Avoid injection within 2-3 hours of consuming carbohydrates or fats, as elevated blood glucose and free fatty acids can inhibit GH secretion.
Reconstitution, Storage & Preparation
Tesamorelin typically arrives as lyophilized (freeze-dried) powder requiring reconstitution before use.
Reconstitution Process:
- Allow vial to reach room temperature
- Use bacteriostatic water (preferred for multi-dose vials) or sterile water
- Inject diluent slowly against vial wall, allowing it to run down the side rather than directly onto powder
- Gently swirl, never shake, until fully dissolved
- The resulting solution should remain clear and colorless
Concentration: Standard reconstitution uses 2 mL bacteriostatic water per 2 mg vial, yielding a 1 mg/mL concentration. This allows convenient dosing with standard insulin syringes.
Storage Guidelines:
- Unreconstituted powder: Refrigerate at 2-8°C (36-46°F), protect from light
- Reconstituted with bacteriostatic water: Refrigerate, use within 14-28 days
- Reconstituted with sterile water: Refrigerate, use within shorter window
- Never freeze reconstituted solution
- Do not use if cloudy or contains particulates